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Many GLP-1s are FDA approved for more than just weight loss, including type 2 diabetes, cardiovascular risk reduction, and even stroke prevention in certain populations, says Supriya Rao, MD, an obesity physician and the director of medical weight loss at Lowell General Hospital in Lowell, Massachusetts

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It is possible that these variants have impaired folding and localisation, although R169W has previously been shown to localise normally to the membrane 53

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