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A physician may need to evaluate persistent vomiting, severe abdominal pain, signs of dehydration, worsening reflux, gallbladder symptoms, low blood sugar risk in patients using diabetes medications, kidney function concerns, unintentional under-eating, rapid weakness or muscle loss, and medication interactions

& Schmierer, K

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Indeed, glutamate is reported to constrict pial arterioles whereas inhibition of glutamate by an ionotropic receptor antagonist dilates arterioles 18