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80,179,204,205 PI3K/AKT and mTOR signaling The PI3K-AKT-mTOR axis plays a central role in orchestrating tumor cell growth, survival, metabolic reprogramming, immune evasion, and apoptosis resistance

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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice