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Sitting at a 90-degree angle crimps the anorectal angle, making it harder for stool to pass

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This includes 10 Phase 3 studies of PF3944, such as the ongoing VESPER-4 trial investigating once-weekly dosing in patients without diabetes, the planned VESPER-5 trial in patients with type 2 diabetes, and the planned VESPER-6 study evaluating once-monthly PF3944 in obesity and overweight