These are promising results, but the studys authors note that more research is needed, and clinicians must also consider potential adverse effects, evaluate the cost-effectiveness of these medications for each patient, and closely monitor for any improvement or worsening of eating disorders and related side effects. That hesitation is shared by the National Eating Disorder Association (NEDA), who published an opinion paper on GLP-1s and eating disorders in 2024, stating: While there is some evidence that GLP-1s can decrease the number of binge eating episodes for those with BED, little is known about the long term physical and psychological impact on those with eating disorders. How GLP-1s could also fuel eating disorders The same mechanisms that make these medications helpful for some could make them harmful for others

Her idea hinged on the fact that Bell's paper showed 'the predicted sequence of GLP- 1 flanked by enzymatic cleavage sites known to release biologically active peptides from prohormones.' As she explains, 'It predicted the sequence of a 37- amino acid-long version of GLP- 1 and compared it with the sequence of glucagon and other peptides in the same family
Its effects tend to be more targeted and often produce noticeable changes in specific problem areas within days to weeks
The GCH1/DHFR/BH4 pathway exerts antioxidant effects independently of the Xc-GSH-GPX4 and NADPH-FSP1-CoQ10 axes (Akiyama et al., 2023)
GLP-1 RAs have been shown to be effective in managing blood sugar in type 2 diabetes