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doi: 10.1093/jn/137.11.2384 135 RiedijkMADe Gast-BakkerDAWattimenaJLVan GoudoeverJB
In Ldlr / Leiden mice, only the combined intervention with nicotinamide riboside, rather than either monotherapy, significantly attenuated obesity and hepatic steatosis, accompanied by coordinated upregulation of genes involved in fatty acid oxidation and insulin signaling (61)
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The key areas are IGF-1, glucose handling, lipids, thyroid context, and fluid-retention symptoms
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