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Higher Market Penetration Oral medications are generally easier for patients to accept and more suitable for long-term treatment
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It can also be considered in cases of resistant melasma or recurrent melasma
This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance
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