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Finally, we consider factors that could limit the impact of these therapies, outlining reasons why our expectations may not be fully realized

Low-Dose Naltrexone (Off-Label Use) How it works: Though not FDA-approved for weight loss, some healthcare providers use low-dose naltrexone off-label for appetite regulation and inflammation control

Zepbound is approved for obesity

Higher body weight may affect the volume of distribution, though standard dosing protocols generally account for this variation

Moreover, the administration of these peptides to healthy individuals for anti-aging or performance enhancement introduces additional ethical and safety considerations, as the long-term effects of chronic exposure in otherwise healthy populations remain unknown