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Additional studies have focused on histopathologic and morphometric changes, with more limited exploration of the mechanisms of action of fluoxetine and curcumin

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Osthole, a coumarin-type phytoestrogen and a major active component of Cnidium monnieri, has been shown in modern pharmacological studies to effectively improve endocrine metabolism in DOR rats, reduce ovarian inflammation and oxidative stress damage, and restore ovarian reserve function by regulating the Nrf2/HO-1/NLRP3 signaling pathway [92]

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Though the recommended daily value is 15 mg, it is generally recognized that 30% to 50% of ingested zinc is not absorbed due to complexing with phytic acid, perspiration loss, fiber transport through the intestines or because of the competition for absorption with copper, iron and calcium

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