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The pentose phosphate shunt has two phases, the oxidative phase (reactions 21 - 23), in which NADPH and pentose-5-phosphate are generated, and the non-oxidative phase (reactions 24 - 28), in which unused pentose-5-phosphate can be converted to other sugar intermediates and then returned to the glycolytic pathway as glyceraldehyde-3-phosphate and fructose-6-phosphate

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Additionally, in the latter study, the changes in redox and methylation metabolism was not analyzed in the published paper

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And this is one of the ways the pharma industry keeps learning, adapting, and working toward improving lives

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