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TGR Enzymatic Assays Assays were performed at 25 C in 0.1 M potassium phosphate (pH 7.4), 10 mM EDTA using 100 M NADPH unless otherwise stated

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reported that inhibition of the Xc- transport system using sulfasalazine, while ineffective as a monotherapy, was highly effective to eliminate AML cell lines when combined with Buthionine sulfoximine (BSO), an inhibitor of glutamyl cysteine synthetase, the first enzyme in the synthesis of GSH