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Therefore, we challenged mice with hepatic-specific PGC-1 overexpression on a chow diet with a subtoxic dose of APAP and we found that PGC-1 overexpression renders the liver more sensitive to APAP damage, mainly due to intense oxidative stress, finally ending up with liver necrosis and mice death
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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
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