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In den untersuchten Dosierungen wurden keine relevanten Nebenwirkungen beobachtet [6]
Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation
Could it make things worse for those of us with stretchy connective tissue
The UK product information includes a warning (though not a formal contraindication) for patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, advising vigilance for symptoms such as neck lumps or hoarseness
doi:10.1073/pnas.0400195101
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