We suppose the change is because the initial doses are enough to keep B12 levels within the desired range
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Shelf life up to 24 months when stored lyophilized
Dosing Protocol Suggested approach for the 50 mg vial format
Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose