They tell us what happens when the most potent molecule in the field meets the patients whose physiology fights back hardest and the answer is that it does very well, just not as well, and at a tolerability cost that goes up in exactly the population least able to absorb it
Notably, the deletion of Slc7a11 (which encodes xCT) in animals results in viable offspring 15 , which suggests that tissues (and potentially tumours) can obtain cysteine from another origin
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About 6 to 7 percent of patients discontinue for side effects in the pivotal trials, which is the benchmark every next-generation GLP-1 is now compared against