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The main findings from the pooled population analysis were as follows: (1) GLP-1RAs were associated with an increased rate of pre-procedural GI symptoms (nausea, vomiting, dyspepsia, abdominal distension) compared to control, (2) GLP-1RA use resulted in an expressive increase in RGC compared to the control, (3) GLP-1RAs improved glycemic control and decreased the rate of rescue insulin administration compared to control, and (4) there was no significant difference between GLP-1RAs and control related to the rates of perioperative hypo or hyperglycemia, postoperative inotropic support, PONV, atrial fibrillation, and 30-day mortality

Although proven effective, GLP-1 RAs have been associated with numerous GI adverse events

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It has also been referenced in studies probing neuronal signalling cascades and receptor activation kinetics in controlled laboratory settings