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Stronger barrier function reduces transepidermal water loss and helps skin maintain its moisture content
This is commonly referred to as neuronal firing. In contrast, influx of negatively charged ions can have inhibitory effects by hyperpolarizing the membrane and thus preventing neuronal firing (15)
This shifts metabolism toward fat oxidation, reduces hepatic glucose production, and improves insulin sensitivity in peripheral tissues
More frequent injections increase cumulative exposure to injection-related discomfort
Overall, the findings suggest potential benefits of GLP-1RA treatment in this high-risk population, although residual confounding and heterogeneity across autoimmune diseases mean the results should not be interpreted as proof of causality
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