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Long-term trends matter more than weekly fluctuations
Chronically high levels of blood glucose can cause inflammation and death of neurons, brain aging, cognitive impairment, and even dementia
The usual Wegovy weight-loss ladder is 0.25 0.5 1.0 1.7 2.4 mg weekly, holding each step at least 4 weeks
IGF-1R is a receptor tyrosine kinase that mediates the actions of IGF1, which binds with high affinity, whereas IGF2 and insulin bind to this receptor with low affinity [23]
However, scarce evidence exists for these AOMs in older adults [10], hence the current narrative will review the evidence for obesity pharmacotherapy in this sub-population
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