glp 1 in development Discovery of GLP-1–Based Drugs for the Treatment of Obesity Market Overview: GLP-1 Agonists and

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19 The dual GIP/GLP-1 RA tirzepatide has demonstrated a similar but sometimes more pronounced GI profile compared with semaglutide in clinical-development programs

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Tirzepatide activates two distinct receptor pathways (GLP-1 and GIP), providing a fresh mechanism if semaglutide alone has plateaued

FDA and the EMA are evaluating new indications for GLP-1 therapies that highlight their cardiovascular benefits