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Many peptides are bio-identical to those naturally produced in the body, making them both effective and well-tolerated
For example, reactive astrocytes in the optic nerve can revert to their quiescent state upon the removal of stressors 43
Supplementation targets these symptoms at their mechanistic root
By incorporating pH-labile chemical linkages that cleave selectively in response to the characteristically acidic extracellular pH of the TME and the even more acidic conditions of endosomal and lysosomal compartments following cellular internalization, or redox-sensitive bonds that rupture upon encountering the markedly elevated glutathione concentrations within cancer cell cytoplasm, or enzyme-responsive substrates that are selectively cleaved by proteases and other enzymes overexpressed within the tumor stroma, intelligent nanocarriers maintain stable drug containment throughout systemic transit and release their payload rapidly and completely only after arriving at the intended intracellular destination
Available at: Jung SY et al (2011): Short-acting nifedipine and risk of stroke in elderly hypertensive patients
