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The Ozempic ladder reaches 2.0 mg weekly, but doubling from 1.0 to 2.0 mg added only about 0.23 percentage points of HbA1c reduction and 0.9 kg of weight loss. Beyond 1.0 mg, most of the added effect is on weight rather than glucose

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Pharmacodynamic endpoints Treatment with survodutide did not lead to any clear dose-dependent reductions in the NASH-related Fib-4 score, APRI and NAFLD fibrosis score relative to placebo (Table 4)