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That said, phentermine still has a role for certain patients, particularly when short-term, oral therapy is preferred or when cost and accessibility are primary concerns

ADA Standards of Care 2025) recommend that patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) (or high risk) should be on a GLP-1 RA with proven CV benefit (or an SGLT2 inhibitor) as part of their regimen, independent of A1c, because of the outcome benefits ( [9] ) ( [144] )

Abbreviations CK: Creatine kinase DIP: l-alanyl-l-glutamine GABA: -Aminobutyrate GSH: Glutathione HSE: Heat shock element HSF: Heat shock factor HSP: Heat shock proteins HSP70: 70-kDa protein family IL: Interleukin LDH: Lactate dehydrogenase LIF: Leukaemia inhibitory factor MCP: Monocyte chemotactic protein MDC: Chemokine derived from macrophage PepT: Intestinal transporter ROS: Reactive oxygen species SLC: Solute carrier TNF: Tumour necrosis factor uPA: Fractalkine and urokinase plasminogen activator VEGF: Vascular endothelial growth factor References Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R

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Materials and methods Study design With approval from the Institutional Review Board of the Samsung Medical Center (SMC IRB 2022-06-079), we retrospectively reviewed the medical records of patients who underwent definitive radiotherapy for localized or locoregional prostate cancer between January 2008 and December 2018 at Samsung Medical Center