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The buildup of toxic proteins in Alzheimers further lowers GSH levels, making the patients more likely to be deficient [32]
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In a study of over 1000 breast cancer patients with diabetes, those taking metformin had an almost 24% lower mortality risk compared with controls, whereas those not taking metformin had an almost 71% higher mortality risk (Hou 2013)
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Triggered by mitochondrial oxidative stress, Ca 2+ overload, dysregulation of iron homeostasis, mitochondrial DNA defects, and disruption of mitochondrial quality control (MQC), programmed cell death subsequently ensues encompassing apoptosis, pyroptosis, necroptosis, and ferroptosis [17]
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