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To ensure efficient depletion had occurred, we created a GFP-tagged knock-in allele of epn-1 (see STAR Methods)

This dual-receptor activation may explain why some patients experience better satiety and metabolism changes on tirzepatide compared to semaglutide alone

Those with BMI 2729.9 kg/m qualify if they have weight-related conditions: type 2 diabetes, hypertension, obstructive sleep apnea, or cardiovascular disease

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