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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12

As long as you follow recommended guidelines and work with a healthcare provider when needed, taking Bvitamins and the neon urine that may accompany them is both safe and beneficial.