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The GTP-bound alpha subunit can move away and activate downstream pathways, and the beta and gamma subunits can also dissociate and trigger complementary pathways
These agents mimic the action of endogenous GLP-1, an incretin hormone released from intestinal L-cells in response to nutrient intake
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This is one of the most frustrating aspects for patients who thought they had adjusted to the medication
The same principle applies to customer service: staff should be trained to answer policy questions with specificity, not canned platitudes, and to escalate complex concerns with transparent handoffs
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