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Weight loss recommendations may be particularly important for patients at highest risk for weight gain and cardiovascular morbidity, such as young/premenopausal patients, postmenopausal patients with estrogen receptorpositive disease on endocrine therapy, and/or preexisting cardiovascular disease risk factors
For example, the phase-3 SURMOUNT-1 trial showed Mayas tirzepatide (Zepbound) led to ~20.9% weight loss vs 3.1% on placebo after 72 weeks ( [18] )
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Schmidt had joined what we might call the great American GLP-1 experiment
This enhanced insulin sensitivity helps the body utilize glucose more efficiently, reducing fat accumulation and promoting weight loss
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