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The prescribing information explicitly states it must be made approximately isotonic prior to use
Skorjanec et al., 2009
[Read More] Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, Ljubanovic D, Coric V, Konjevoda P, Petek M, Rucman R, Turkovic B, Perovic D, Mikus D, Jandrijevic S, Medvidovic M, Tadic T, Romac B, Kos J, Peric J, Kolega Z
There is also a practical argument for the stack
This difference supports a concept of testable synergy rather than simple redundancy
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