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Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia
They do not shut it down completely, which would compromise immune function, but rather dial it back toward normal levels
Do not remove tablets from blister pack until use
Nature 580 , 269273 (2020)
Carbapenems, especially meropenem and ertapenem, inhibit the action of APEH, allowing more VPA to remain as the inactive, readily eliminated conjugate
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