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These molecules facilitate the closure of ATP-sensitive potassium channels (K ATP ) and the opening of voltage-dependent calcium channels, causing an influx of calcium that triggers the release of insulin granules (Zheng et al., 2024)
Attaching a 16-carbon side chain (palmitic acid) to the peptide allowed the molecule to bind to the abundant blood protein albumin and keep it in circulation
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In addition, it can delay gastric emptying, enhance satiety, and reduce food intake
GnRH regulates gonadotropin gene expression through NADPH/dual oxidase-derived reactive oxygen species
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