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Common side effects such as nausea, vomiting, diarrhoea, and dehydration can temporarily reduce energy levels, particularly during the first few weeks of treatment or after dose increases

Authorship Contributions SJM, JB and TAB contributed with study conception, study design, data interpretation, critical manuscript revision and final manuscript approval

Liraglutide (Saxenda): The Original Weight Loss GLP-1 Liraglutide was the first GLP-1 receptor agonist to receive FDA approval specifically for chronic weight management, doing so in 2014 under the brand name Saxenda

Unlike single-pathway peptides, Retatrutide is designed to engage multiple metabolic pathways

What Is GLP-1 for Weight Loss