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Ghadimi M, Foroughi F, Hashemipour S, Rashidi Nooshabadi M, Ahmadi MH, Ahadi Nezhad B, et al
Managing Intolerable Side Effects Semaglutide and tirzepatide are both known for causing gastrointestinal side effects
While side effects are often cited as a reason for GLP-1 non-adherence, the gap in persistence for the same molecule reflects deeper behavioral and systemic challenges
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Rybelsus (oral semaglutide), for example, requires taking it on an empty stomach with no more than 4 ounces of water, then waiting at least 30 minutes before eating, drinking, or taking other medications
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