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Chetomin, derived from chaetomium globosum, is a dithiobiketopiperazine metabolite that disrupts the binding of HIF-1 and HIF-2 to p300, thereby attenuating the HIF pathway 24,55 (Figure 3)

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Gastrointestinal Distress: Acute systemic loads exceeding 10 mg frequently trigger nausea, severe cramping, and gastrointestinal rejection

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Intra-articular injection (into the joint space) was used in the Lee et al