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The inflammatory markers monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor (TNF- ), were reduced by treatment with exendin-4 in response to lipopolysaccharide in cultured peritoneal macrophages harvested from mice [65]
doi: 10.1016/j.cmet.2021.07.007 44 ZhangXZhangYWangPZhangSYDongYZengGet al
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GLP-1 may exert its effects locally via the vagus nerve before being degraded by DPP-4 in circulation
Others describe gastrointestinal problems that seem worse than what they experienced with the brand-name product
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