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While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord

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All data are expressed as the mean SD from at least three biological replicates, and comparisons between the two groups were performed with a nonparametric method (MannWhitney U test)

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A 50mg vial is consumed across a shorter working life, so one reconstituted stock takes fewer stopper penetrations, less light exposure and fewer freeze-thaw cycles before it is finished