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John Sharretts Diabetes, Lipid Disorders Obesity (Center for Drug Evaluation and Research) FDA serious conditions FDA tirzepatide (Zepbound) unmet medical need (Centers for Disease Control and Prevention CDC) 70% weight-related condition 1 Tirzepatide active ingredient Zepbound dual GLP-1/ GLP-1 receptor agonist receptors glucagon-like peptide-1 GLP-1 glucose-dependent insulinotropic polypeptide (GIP) (appetite) 2565 tirzepatide Mounjaro FDA reduced calorie diet increased physical activity 2 18 tirzepatide (Zepbound) FDA chronic weight management 2 phase 3 double-blind, randomized, controlled trial SURMOUNT-1 SURMOUNT-2 SURMOUNT-1 18 weight-related condition 1 2,539 4 tirzepatide (Zepbound) 5 mg, 10 mg 15 mg placebo 72 coprimary endpoints % 72 (baseline) 5% mean body weight 104.8 kg mean BMI was 38.0 94.5% BMI 30 30 SURMOUNT-1 New England Journal of Medicine (NEJM) 21 2565 mean percentage change 72 -15.0%, -19.5% -20.9% tirzepatide (Zepbound) 5 mg, 10 mg 15 mg -3.1% placebo % 5% 85%, 89% 91% tirzepatide (Zepbound) 5 mg, 10 mg 15 mg 35% placebo 50% 57% tirzepatide (Zepbound) 10 mg 15 mg 20% 20% 3% placebo SURMOUNT-1 tirzepatide (Zepbound) overall safety tolerability profiles incretin-based therapies FDA adverse events tirzepatide (Zepbound) 5 mg, 10 mg 15 mg placebo nausea, diarrhea, vomiting constipation adverse events severity mild to moderate SURMOUNT-2 18 weight-related condition 2 938 3 tirzepatide (Zepbound) 10 mg 15 mg placebo 72 co-primary objectives tirzepatide (Zepbound) 10 mg 15 mg placebo mean percentage change in body weight 72 percentage of participants 5% mean bodyweight 100.7 kg BMI 36.1 kg/m 2 HbA 1c 2-3 8.02% SURMOUNT-2 Lancet 19 2566 tirzepatide (Zepbound) 10 mg 15 mg -12.8% -14.7% 72 -3.2% placebo 7983% tirzepatide (Zepbound) 10 mg 15 mg 5% 32% placebo 39.7% 48.0% tirzepatide (Zepbound) 10 mg 15 mg 15% 72 2.7% placebo tirzepatide (Zepbound) 10 mg 15 mg placebo mean percentage change in body weight 72 percentage of participants 5% : www.fda.gov, www.drugs.com, www.nejm.org, www.medpagetoday.com, www2.diabetes.org

Compared to stem cell therapy, PRP is more accessible and has a longer track record in sports medicine and orthopedics

Life in the Lizard Slow Lane: Gila Monsters Have Low Rates of Energy Use and Water Flux Thermal and Behavioral Ecology of the Mexican Beaded Lizard (Heloderma horridum) (MSc)

After navigating the complexities of acute care and large healthcare systems, Traci wanted to practice medicine that meets people before they reach a crisis