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The effects appear lasting, and the source points to changed anatomy and reduced stomach breakdown of alcohol as part of the reason

Data Availability No new data was generated from this manuscript

In SURMOUNT-5, once weekly tirzepatide at the maximum tolerated dose (MTD 10 mg or 15 mg) compared with semaglutide (MTD 1.7 mg or 2.4 mg) resulted in significantly greater body weight reduction in adults living with obesity without T2D

Chronic exposure to GLP-1Ra appears to be essentially neutral on both 2D systolic and diastolic function, irrespective of LV EF

As evidence mounts, pharmaceutical stakeholders highlight its significance in chronic weight management