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363 In hypoxic tumors, antagonizing HIF-1 or its transcriptional targets (e.g., PDK1/3, MT2A) may prevent mitochondrial copper sequestration and promote lethal copper accumulation
A.Jazmin Silvero C.M.RodrguezA.ArmonelliS.et al (2020)
Titration intervals shorter than 7 days do not allow sufficient time for steady-state plasma levels to establish or for delayed responses to manifest, leading to premature dose escalation and increased risk of side effects
It means they may deserve the chance to be studied properly
