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The nuclear factor E2 related factor 2 (Nrf2/NFE2L2) has been proved to play a key role in neurodegenerative disease treatment and ferroptosis regulation

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Furthermore, the authors validated the capacity of MnO 2 -coated mesoporous silica nanoparticles (MSNs) to control drug release, and the camptothecin (CPT)-loaded MnO 2 -MSNs showed sustained CPT release after the addition of GSH (Figure 1G)