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Clinical trials show average weight loss of 15-17% of body weight with semaglutide and 20-22% with tirzepatide over 68-72 weeks

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Limit alcohol intake, avoid doubling a missed dose, and refrain from driving if dizziness or weakness occurs

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Patients with specific GIPR genotypes may tolerate compounded tirzepatide (which activates both pathways) better than semaglutide despite higher initial nausea expectations

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