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Self-assembling peptide hydrogels: design, mechanisms, characterization, and biomedical applications
Under unstressed conditions, MANF and glucose-regulated protein 78 (GRP78) are expressed at low levels
The autophagy adaptor p62/SQSTM1, essential for targeting ubiquitinated substrates to autophagosomes, is mutated in ALS and FTD, where impaired p62 function results in aggregation-prone protein accumulation and neuronal toxicity
We're going to examine all of this in more detail shortly, but first
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