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In diabetic rats, which are known to exhibit severely delayed wound healing, PIC treatment demonstrated elevated glutathione and ascorbic acid levels, improved epithelialization, and enhanced activation of fibroblasts and mast cells in the wound area

Only the administration of insulin directly into the portal vein will really treat the metabolic derangement present in T1DM (Fig

Serious allergic reactions are uncommon but require urgent care

Care must be taken with regard to using these supplements, for the reasons noted below

What we do have is a growing body of laboratory and animal research, early clinical experience, and a clearer understanding of the questions that still need to be answered