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At position 8, the native alanine is replaced by the protease-resistant amino acid -aminoisobutyric acid (Aib)
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A fast, decisive insertion passes through the pain-sensitive skin layer in a fraction of a second
Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease
GLP-1 also protects HT22 cells against oxidative stress-induced cell death (183)
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