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However, in randomized clinical trials in type 2 diabetes, semaglutide resulted in up to 3 times greater weight loss compared with other GLP-1RAs and up to twice as much in patients with obesity, approaching 15 kg (35)
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These medications work by mimicking the action of naturally occurring incretin hormones, which enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways
(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug
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