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The key practical difference in tolerability: tirzepatides GIP component may partially offset some GI effects of GLP-1 agonism through GIPs effect on gastric motility which may explain why some patients who discontinue semaglutide due to GI side effects tolerate tirzepatide better, though this is not consistently demonstrated across all patients
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Over the counter GLP-1 supplements use ingredients such as ashwagandha, green tea extract, berberine, chromium, and saffron
Titration gives the gastrointestinal system time to adjust at each dose before the next increase, keeping the adaptation ahead of the dose
JAMA, 325(14), 14141425
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