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Alterations in the volume of distribution and clearance resulting from other mechanisms of action (eg, reduced fat mass, changes in cytochrome P450 activity, and glomerular filtration rate) are key factors in determining pharmacokinetics

Assessing GSH status is critical for studying oxidative stress mechanisms and downstream effects of oxidative damage

This can make it harder to sustain long-term weight loss

Important interactions and contraindications should be reviewed with your prescribing clinician, particularly if you're taking insulin or other diabetes medications, have a history of pancreatitis, or have significant kidney or gastrointestinal conditions