While enteral administration offers several advantages over other routes of drug delivery in terms of convenience, promoting medication compliance, it faces several obstacles, of which the most widely recognized are inefficient absorption owing to physical barriers and an acidic microenvironment, along with degradation by proteases and the first-pass metabolism in the liver
Wan L, Battle DJ, Yong J, Gubitz AK, Kolb SJ, et al
A lot of people dont bring up diarrhea on GLP-1 medications because they feel its awkward or think its just part of it. I make a point to ask, because bowel changes can signal dehydration, food triggers, or that the dose is moving too fast
These functions occur via binding and activation of their cognate secretin-like (class B) G protein-coupled receptors (GPCRs)
This was reported previously by Ibrahim et al (2021) and Singh and Kumar (2019)