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While GHK-Cu is generally well-tolerated in topical research, certain contraindications or precautions should be considered, especially for systemic research or in specific populations: Systemic Research: For systemic applications, GHK-Cu is generally not recommended for subjects who are pregnant, breastfeeding, have active cancer, or suffer from Wilsons disease (a condition involving copper accumulation)

However, blocking NF-B may bring about undesirable side effects, such as the broad suppression of innate immunity due to the lack of specificity of the relevant treatment and the significance of NF-B in cellular homeostasis (66)

Weeks 3 to 4

PMID 13854292