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This impairs capillary integrity, allowing peripheral iron, lymphocytes, and cytokines to infiltrate the brain parenchyma, thereby amplifying local inflammation and iron dysregulation ( Moreover, ferroptosis-associated damage molecules such as high mobility group box-1 (HMGB1) and chemokine CXCL2 can directly impair the functional stability of brain microvascular endothelial cells

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TRT can absolutely improve energy, mood, and drive, but for a subset of men, especially in the early months, it als

10.1177/03635465221077101 14 El HaddadM.JeanE.TurkiA.HugonG.VernusB.BonnieuA.et al (2012)