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In cancer patients, iron loss could also be due to diarrhea, both as a cancer symptom and as a consequence of anti-neoplastic drugs (4, 354)

It also participates in the regulation of apoptosis pathways, with HSPD1 as a representative member that is localized in the mitochondrial matrix and functions as a molecular chaperone in an ATP-dependent manner (Singh et al., 2024a)

In fact, by continuously depriving the liver of esterified fatty acids and inhibiting the hepatic glycolytic pathway, glucagon promotes the production of ketone bodies [41,42,43] Hepatic ketogenesis is boosted as a result, and mitochondrial fatty acid oxidation is improved [14, 43]

3a, Supplementary Figs

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